超灵敏、多指标、快速与小型化的生物检测是当前临床疾病个性化精准诊断发展的重要趋势。纳米功能材料作为识别、捕获和操控待检靶分子的载体与信号标记材料，为高性能的生物检测技术提供了强有力的工具。课题组的研究方向聚焦在可控地制备具有精密表、微观结构的纳米功能复合材料并在此基础上发展基于纳米功能（智能）材料与纳米技术的生物检测新方法。

1、原位复合法制备纳米TiO2抗紫外纤维，获2006年高等学校科学研究优秀成果奖（科学技术）技术发明一等奖（排名第二）

2、上海高等学校优秀青年教师（2008年）

3、磁性纳米微球可控制备技术与分子诊断试剂盒，获2013年上海市技术发明二等奖（排名第二）

4、超顺磁性纳米颗粒材料制备及其生物医学应用，获2015年高等学校科学研究优秀成果奖（科学技术）自然科学二等奖（排名第二）

1)  Wang PR, Xu P, Wang PP, Deng LL, Gu HC, Xu H*,  Improvement of Protein Immobilization and Bioactivity of Magnetic Carriers Using a Brushed Beads-on-Beads Structure, ACS Applied Materials & Interfaces , 2015, 7, 24390−24395

2)  Qu ZY, Xu H*, Gu HC*, Synthesis and Biomedical Applications of Poly((meth)acrylic acid) Brushes， ACS Applied Materials & Interfaces,2015, 14537–14551

3)  Qu ZY, Xu H*, Chen KM, Gu HC*, Ultrasensitive ELISA Using Enzyme-loaded Nanospherical Brushes as Labels, Analytical Chemistry, 2014,86, 9367−9371

4)  Qu ZY, Chen KM, Gu HC, Xu H*, Covalent Immobilization of Proteins on 3D Poly(acrylic acid) Brushes: Mechanism Study and a More Effective and Controllable Process, Bioconjugate Chemistry, 2014, 25, 370-378, Cover Article

5)  Wang YL*, Wang FYK, Chen BD, Xu H*, and Shi DL, Facile One-Pot Synthesis of Yolk-shell Superparamagnetic Nanocomposites via Ternary Phase Separations, Chemical Communications, 2011, 47, 10350-10352.

6)  Xu YW, Xu H*, Gu HC, Controllable Preparation of Epoxy-functionalized Magnetic Polymer Latexes with Different Morphologies by Modified miniemulsion polymerization, Journal of Polymer Science: Part A: Polymer Chemistry, 2010, 48, 2284–2293

7)  Xu QF, Xu H*, Gu HC, Li JB*, Wang YY, Wei M, Development of Lateral flow Immunoassay System Based on Superparamagnetic Nanobeads as Labels for Rapid Quantitative Detection of Cardiactroponin I, Materials Science and engineering C, 2009, 29, 702–707

8)  Qiang WL, Wang YL, He P, Xu H*, Gu HC, and Shi DL, Synthesis of Asymmetric Inorganic/Polymer Nanocomposite Particles via Localized Substrate Surface Modification and Miniemulsion Polymerization, Langmuir, 2008, 24, 606-608

9)  Xu H, Tong NH, Cui LL, Lu Y, Gu HC*, Preparation of Hydrophilic Magnetic Nanospheres with High Saturation Magnetization, Journal of Magnetism and Magnetic Materials, 2007, 311,125–130

10)  Xu H, Cui LL, Tong NH, Gu HC*, Development of High Magnetization Fe3O4/Polystyrene/Silica Nanospheres via Combined Miniemulsion/Emulsion Polymerization, Journal of the American Chemical Society, 2006, 128, 15582-15583

    · 2015年教育部自然科学二等奖

1) Yao Wang, Hao Song, Chengzhong Yu*, and Hongchen Gu*,From Helixes to Mesostructures: Evolution of Mesoporous Silica Shells on Single-Walled Carbon Nanotubes，Chemistry of Materials，January 11, 2016; 28(3):936-942

2) Zhenyuan Qu, Hong Xu*, and Hongchen Gu*，Synthesis and Biomedical Applications of Poly((meth)acrylic acid) Brushes，ACS Applied Materials & Interfaces，15 July 2015， 7 (27), 14537–14551

3) Yao Wang and Hongchen Gu*，Core–Shell-Type Magnetic Mesoporous Silica Nanocomposites for Bioimaging and Therapeutic Agent Delivery，Advanced Materials，January 21, 2015， 27(3):576-585

4) Ying Zhu, Hong Xu, Kaimin Chen, Jianping Fu and Hongchen Gu*，Encoding through Host/Guest Structure: Construction of Multiplexed Fluorescent Beads，Chemical Communications，23/09/2014; 50(90),14041-14044

5) Xu Li, Yijie Chen, Mingqi Wang, Yongjie Ma, Weiliang Xia , Hongchen Gu*，A mesoporous silica nanoparticle – PEI – Fusogenic peptide system for siRNA delivery in cancer therapy，Biomaterials， January 2013，34(4), 1391–1401

6) Kaihua Chen, Jixi Zhang and Hongchen Gu*，Dissolution from inside: A unique degradationbehaviour of core-shell magnetic mesoporous silica nanoparticles and the effect of polyethyleneimine coating，Journal of Materials Chemistry，NOV 7 2012，22(41), 22005-22012

7) Qian Liu, Jixi Zhang, Weiliang Xia and Hongchen Gu*，Magnetic field enhanced cell uptake efficiency of magnetic silica mesoporous nanoparticles， Nanoscale，April 2012，4(11):3415-3421

8) Xu Li, Qian Reuben Xie, Jixi Zhang, Weiliang Xia*, Hongchen Gua*， The packaging of siRNA within the mesoporous structure of silica nanoparticles， Biomaterials，December 2011，32(35):9546-9556